Black Seed Oil - Organic
Black seed oil has a long history both medicinally and spiritually dating back 3000 years. This powerful seed and the oil it contains has been used and spoken about from Hippocrates to Cleopatra and has also been referenced in some of the oldest herbal books in history, including the Bible.
Black seed oil was also found in Tutankhamen’s tomb because it was believed to be important in the afterlife. When the tomb was resumed there were seeds found in the tomb preserved in honey and it was said to still be edible. This powerful seed not only has the history, but also has modern science to back it up.
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Black seed (also known as nigella seeds) is a member of the buttercup family and its seeds are dark, thin, and crescent shaped with approximately 100 nutritional chemical constituents present (new nutritional compounds are still being identified). One of the constituents that has been studied by modern science as a major player in this food is thymoquinone. Some of the other identified constituents are beta sitosterol, myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, arachidonic acid, protein, vitamin B1, vitamin B2, vitamin B3, folic acid, calcium, iron, copper, zinc, and phosphorous. Since 1959, black seed oil has been the subject of more than 200 different studies at universities and laboratories.
Black Seed is Packed with Nutrients
The compounds in black cumin seed oil are a unique mixture that may have multiple supportive effects. Antioxidants which may support the body’s ability to reduce oxidation, support antioxidant systems on a cellular level and possibly prevent damage caused by free radicals. Compounds present in this food may support the body’s ability to have a healthy inflammation response. It may do this in 3 possible ways. First, by possibly aiding in the suppression of NF-KappaB which is a master regulator of inflammation by preventing inflammation pathways from becoming over stimulated.
Next, it may possibly support the inhibition of a variety of enzymatic systems that produce leukotrienes and prostaglandins like 5-LOX and COX1. Finally it may possibly support the reduction of a precursor of molecular inflammation called 5-HETE. Black seed oil may have a possible direct effect on the body’s ability to have a healthy immune response by inciting an acute inflammatory response to infection.
Black Seed has a rich historical and religious background
It has been said that if you nourish what is on the inside it will show on the outside as well. It is believed that Cleopatra’s beauty came from the use of this powerful seed oil. Rich in nourishing compounds, vitamins and minerals necessary for the possible repair and recovery of one’s hair, skin and nails. Science has said that many of today’s skin issues have a direct connection to autoimmune issues. Much of the science with black seed oil and skin health goes back to its ability to support the body in having a healthy inflammation and immune system response. This may be one of the links that puts it all together. Another possible connection is the very impressive essential fatty acid profile having 26 different fatty acids present with majority being the following: 8.51% palmitic acid, linoleic acid 42.76%, oleic acid 15.59%, epa 5.98%, dha 2.97% and eicosatrienoic acid 4.71%.
Black Seed (N. sativa) has been widely studied for therapeutic possibilities
Here are a couple of interesting study results using black seed oil for a variety of different issues, yet, all related to the body’s inflammation response. In one human study, 40 women with rheumatoid arthritis had a one month washout period where they took a placebo twice daily. This was followed up with one month of using 500mgs twice daily of the black seed oil. The study used a standard 28 point scale to assess their results which showed improvement across the board. A total of 42.5% of the patients showed overall reduction in symptoms. Another study showed that animals that were supplemented showed improvement in both the lowering of LDL and raising of HDL levels.
The black seed oil benefits may be numerous
Due to the variety of ways this food may support human health and the impressive body of science and history backing it up, we would not be surprised if you see much more to come from this powerful superfood. We strongly encourage you to make this an everyday staple in your life.
Some possible traditional uses of Raw Organic Black Seed Oil may include:
- May support a healthy immune system response
- May support a healthy inflammation response
- May support a healthy antioxidant response
- May support the health of hair, skin, and nails
- May support a healthy histamine and allergy response
- May support healthy digestion
- May support cardiovascular health
- May support a healthy response to invading bacterial infection
- May support a variety of different regulatory pathways in the body
- Possible anti-fungal and anti-yeast properties
- Complex fatty acid profile
- Complete body of science and history supporting its ability to nourish the body
Powerful Phytonutrients, Vitamins, Minerals and Nutrition in our Fresh, Raw, Organic Black Seed Oil include:
- Tricyclene, Camphene, β-Pinene, 2,4, nigellone, Dithymoquinone, Sabinene, β-Myrcene, 1,8-Cineole, α-Terpinene, Limonene, γ-Terpinene, cis-Sabinene hydrate, allo-Ocimenol, Linalool, Terpinolene, trans-Sabinene hydrate, Terpinen-1-ol, 1,5,8-p-Menthatriene, Nonane, Borneol, RI, MS, Pinocarvone, trans-Dihydrocarvone, Dihydrocarvone, Ocimenone (E), Thymoquinone, Thymol, Carvacrol, 2-Undecanone, n-Octyl isobutyrate, α-Longipinene, Citronellyl acetate, Thymohydroquinone methyl ether, Cyclosativene, tanethole, α-Longicyclene, 4-terpineol, beta sitosterol, (10)-Thujadiene, myristic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, Oxygenated monoterpenes, Sesquiterpene hydrocarbons, Oxygenated sesquiterpenes, Diterpenes, Alkane, Alkenes
- Fatty acids, Fatty acid esters, arachidonic acid
- Vitamin B1, vitamin B2, vitamin B3, folic acid
- Minerals: Calcium, iron, copper, zinc, and phosphorous
- Epa, Dha, α-Copaene, α-Longifolene, (Z)-Caryophyllene, β-Caryophyllene, Thymohydroquinone dimethylether, RI, MS, Aromadendrene, Thymohydroquinone, Davanone, 8-Heptadecene, Dihydrofarnesyl acetate, Pimaradiene, Palmitic acid, Pimara-8(14),15-diene, Octadecanoic acid, Quinones, Monoterpene
For internal use mix 1 teaspoon (5 ml) with honey, cold or warm dishes, or pure before meals.
For external use apply to dry skin, acne, eczema, wrinkles, scars, stretch marks, minor wounds, rashes, bedsores and other minor skin irritations.
Certifications: USDA Certified Organic.
Ingredients: Raw Black Seed Oil.
Parts Used: Black Seed (oil only).
Typical smell and flavor profile: Smoky and earthy flavor.
Common appearance and texture: Black oil.
Botanical Name: Nigella sativa L.
Other Names: Nigella seed, Great pignut, Kalaunji, upakunchika, nigella, Kalonji, Black cumin seeds, kala jeera, Susavi, Sthulajiraka, Blackseed, Upakunci, Black Cumin, Nigella seed, fennel flower, black caraway, nutmeg flower, black seeds, haba barakah, Roman coriander, Black caraway seeds.
Origin: Grown and cold pressed in India. Packaged with care in Florida, USA.
How to Maintain Optimum Freshness
ZNaturalFoods.com offers Organic Black Seed Oil packaged in an airtight, resealable, dark glass bottle to retain optimum freshness and to preserve maximum potency.
Keep your Organic Raw Black Seed Oil in a cool, dark, dry place.
About Z Natural Foods
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1. Qidwai W, et al Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial . J Altern Complement Med. (2009)
2. The medicinal potential of black seed (Nigella sativa) and its components
3. Ahmad A, et al A review on therapeutic potential of Nigella sativa: A miracle herb . Asian Pac J Trop Biomed. (2013)
4. Ali BH, Blunden G Pharmacological and toxicological properties of Nigella sativa . Phytother Res. (2003)
5. Işik H, et al Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients . Med Princ Pract. (2010)
6. Salem ML Immunomodulatory and therapeutic properties of the Nigella sativa L. seed . Int Immunopharmacol. (2005)
7. Chakravarty N Inhibition of histamine release from mast cells by nigellone . Ann Allergy. (1993)
8. Chemical composition and microflora of black cumin (Nigella sativa L.) seeds growing in Saudi Arabia
9. Houghton PJ, et al Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation . Planta Med. (1995)
10. Nickavar B, et al Chemical composition of the fixed and volatile oils of Nigella sativa L. from Iran . Z Naturforsch C. (2003)
11. Novel lipid constituents identified in seeds of Nigella sativa (Linn)
12. Nutritional profile of indigenous cultivar of black cumin seeds and antioxidant potential of its fixed and essential oil
13. Chemical composition of Nigella sativa L. seeds
14. Keyhanmanesh R, et al The main relaxant constituents of nigella sativa methanolic fraction on Guinea pig tracheal chains . Iran J Allergy Asthma Immunol. (2013)
15. Nigellidine — A new indazole alkaloid from the seeds of Nigella sativa
16. Ali Z, et al Nigellidine-4-O-sulfite, the first sulfated indazole-type alkaloid from the seeds of Nigella sativa . J Nat Prod. (2008)
17. Morikawa T, et al Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa . Org Lett. (2004)
18. Morikawa T, et al Nigellamines A3, A4, A5, and C, new dolabellane-type diterpene alkaloids, with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin . Chem Pharm Bull (Tokyo). (2004)
19. Mehta BK, Pandit V, Gupta M New principles from seeds of Nigella sativa . Nat Prod Res. (2009)
20. Quantification and diversity in the black seeds (Nigella sativa L.): Gene stock of Pakistan for their composition of mineral nutrients
21. el Tahir KE, Ashour MM, al-Harbi MM The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action . Gen Pharmacol. (1993)
22. Gali-Muhtasib H, Roessner A, Schneider-Stock R Thymoquinone: a promising anti-cancer drug from natural sources . Int J Biochem Cell Biol. (2006)
23. Burits M, Bucar F Antioxidant activity of Nigella sativa essential oil . Phytother Res. (2000)
24. Ghosheh OA, Houdi AA, Crooks PA High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.) . J Pharm Biomed Anal. (1999)
25. STUDIES ON THE CHEMICAL CONSTITUTION OF EGYPTIAN NIGELLA SATIVA L. SEEDS. II1) THE ESSENTIAL OIL
26. Antibacterial Activity of Thymoquinone and Thymohydroquinone of Nigella sativa L. and Their Interaction with Some Antibiotics
27. Worthen DR, Ghosheh OA, Crooks PA The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L . Anticancer Res. (1998)
28. He SM, et al Structural and functional properties of human multidrug resistance protein 1 (MRP1/ABCC1) . Curr Med Chem. (2011)
29. Al-Jenoobi FI, et al Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects . Drug Metab Lett. (2010)
30. Alkharfy KM, et al Lepidium Sativum but not Nigella sativa Affects Carbamazepine Disposition in an Animal Model . Drug Metab Lett. (2013)
31. Magnusson MO, et al Pharmacodynamics of carbamazepine-mediated induction of CYP3A4, CYP1A2, and Pgp as assessed by probe substrates midazolam, caffeine, and digoxin . Clin Pharmacol Ther. (2008)
32. Kerr BM, et al Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation . Biochem Pharmacol. (1994)
33. Al-Jenoobi FI, et al Effects of Nigella sativa and Lepidium sativum on Cyclosporine Pharmacokinetics . Biomed Res Int. (2013)
34. Noble S, Markham A Cyclosporin. A review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (Neoral) . Drugs. (1995)
35. Alkharfy KM, et al Effects of Lepidium sativum, Nigella sativa and Trigonella foenum-graceum on Phenytoin Pharmacokinetics in Beagle Dogs . Phytother Res. (2013)
36. Chhun S, et al The cytochrome P-450 2C9/2C19 but not the ABCB1 genetic polymorphism may be associated with the liver cytochrome 3A4 induction by phenytoin . J Clin Psychopharmacol. (2012)
37. Wang H, et al Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin . J Biol Chem. (2004)
38. Gilani AH, et al Bronchodilator, spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji): a traditional herbal product with multiple medicinal uses . J Pak Med Assoc. (2001)
39. Sanz P AMP-activated protein kinase: structure and regulation . Curr Protein Pept Sci. (2008)
40. Benhaddou-Andaloussi A, et al Multiple molecular targets underlie the antidiabetic effect of Nigella sativa seed extract in skeletal muscle, adipocyte and liver cells . Diabetes Obes Metab. (2010)
41. Benhaddou-Andaloussi A, et al The In Vivo Antidiabetic Activity of Nigella sativa Is Mediated through Activation of the AMPK Pathway and Increased Muscle Glut4 Content . Evid Based Complement Alternat Med. (2011)
42. The biochemical consequences of hypoxia
43. Owen MR, Doran E, Halestrap AP Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain . Biochem J. (2000)
44. Turner N, et al Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action . Diabetes. (2008)
45. Le PM, et al The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat . J Ethnopharmacol. (2004)
46. Antidiabetic Activity of Nigella sativa. Seed Extract in Cultured Pancreatic β-cells, Skeletal Muscle Cells, and Adipocytes
47. Allan AM, Harris RA gamma-Aminobutyric acid agonists and antagonists alter chloride flux across brain membranes . Mol Pharmacol. (1986)
48. Krishek BJ, Moss SJ, Smart TG A functional comparison of the antagonists bicuculline and picrotoxin at recombinant GABAA receptors . Neuropharmacology. (1996)
49. Raza M, et al Potentiation of Valproate-induced Anticonvulsant Response by Nigella sativa Seed Constituents: The Role of GABA Receptors . Int J Health Sci (Qassim). (2008)
50. Hosseinzadeh H, Parvardeh S Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice . Phytomedicine. (2004)
51. Gilhotra N, Dhingra D Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels . Pharmacol Rep. (2011)
52. El-Mahmoudy A, et al Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages . Int Immunopharmacol. (2002)
53. Harvey BH, et al Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus . Psychopharmacology (Berl). (2004)
54. Robello M, et al Nitric oxide and GABAA receptor function in the rat cerebral cortex and cerebellar granule cells . Neuroscience. (1996)
55. Duan Y, et al Methylene blue blocks cGMP production and disrupts directed migration of microglia to nerve lesions in the leech CNS . J Neurobiol. (2003)
56. Al-Ghamdi MS The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa . J Ethnopharmacol. (2001)
57. Bin Sayeed MS, et al The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers . J Ethnopharmacol. (2013)
58. Akhtar M, et al Neuroprotective effects of chloroform and petroleum ether extracts of Nigella sativa seeds in stroke model of rat . J Pharm Bioallied Sci. (2013)
59. Hosseinzadeh H, et al Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats . Med Sci Monit. (2005)
60. Akhondian J, et al The effect of thymoquinone on intractable pediatric seizures (pilot study) . Epilepsy Res. (2011)
61. Dantzer R, et al Inflammation-associated depression: from serotonin to kynurenine . Psychoneuroendocrinology. (2011)
62. Maes M, et al The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression . Metab Brain Dis. (2009)
63. Hashioka S Antidepressants and neuroinflammation: Can antidepressants calm glial rage down . Mini Rev Med Chem. (2011)
64. Howren MB, Lamkin DM, Suls J Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis . Psychosom Med. (2009)
65. Dowlati Y, et al A meta-analysis of cytokines in major depression . Biol Psychiatry. (2010)
66. Dunn AJ, Swiergiel AH, de Beaurepaire R Cytokines as mediators of depression: what can we learn from animal studies . Neurosci Biobehav Rev. (2005)
67. Hosseini M, et al The effects of Nigella sativa hydro-alcoholic extract and thymoquinone on lipopolysaccharide - induced depression like behavior in rats . J Pharm Bioallied Sci. (2012)
68. Bin Sayeed MS1, et al Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males . J Ethnopharmacol. (2014)
69. Nigella sativa Oil Enhances the Spatial Working Memory Performance of Rats on a Radial Arm Maze
70. Seif AA Nigella sativa attenuates myocardial ischemic reperfusion injury in rats . J Physiol Biochem. (2013)
71. Dehkordi FR, Kamkhah AF Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension . Fundam Clin Pharmacol. (2008)
72. Datau EA, et al Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male . Acta Med Indones. (2010)
73. Sabzghabaee AM, et al Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial . Med Arh. (2012)
74. Bamosa AO, et al Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus . Indian J Physiol Pharmacol. (2010)
75. Najmi A, et al Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome . Int J Diabetes Dev Ctries. (2008)
76. Hamed A, Alobaidi A Effect of Nigella Sativa and Allium Sativum Coadminstered with Simvastatin in Dyslipidemia Patients: A Prospective, Randomized, Double-blind Trial . Antiinflamm Antiallergy Agents Med Chem. (2013)
77. Krieger M The other side of scavenger receptors: pattern recognition for host defense . Curr Opin Lipidol. (1997)
78. Woollard KJ Immunological aspects of atherosclerosis . Clin Sci (Lond). (2013)
79. Mahmood MS, et al The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide production . Phytother Res. (2003)
80. Mat MC, Mohamed AS, Hamid SS Primary human monocyte differentiation regulated by Nigella sativa pressed oil . Lipids Health Dis. (2011)
81. El-Dakhakhny M, et al The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions . Planta Med. (2002)
82. Rchid H, et al Nigella sativa seed extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets . Fundam Clin Pharmacol. (2004)
83. Kanter M, et al Partial regeneration/proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats . Tohoku J Exp Med. (2003)
84. Comparative Study on the Medicinal Plants Most Recommended by Traditional Practitioners in Morocco and Canada
85. Al-Awadi FM, Khattar MA, Gumaa KA On the mechanism of the hypoglycaemic effect of a plant extract . Diabetologia. (1985)
86. al-Awadi F, Fatania H, Shamte U The effect of a plants mixture extract on liver gluconeogenesis in streptozotocin induced diabetic rats . Diabetes Res. (1991)
87. Hasani-Ranjbar S, Jouyandeh Z, Abdollahi M A systematic review of anti-obesity medicinal plants - an update . J Diabetes Metab Disord. (2013)
88. Tripathi YB, Chaturvedi AP, Pandey N Effect of Nigella sativa seeds extracts on iNOS through antioxidant potential only: crude/total extract as molecular therapy drug . Indian J Exp Biol. (2012)
89. Haq A, et al Nigella sativa: effect on human lymphocytes and polymorphonuclear leukocyte phagocytic activity . Immunopharmacology. (1995)
90. Majdalawieh AF, Hmaidan R, Carr RI Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity . J Ethnopharmacol. (2010)
91. Anti-asthmatic and Anti-allergic Effects of Thymoquinone on Experimentally- Induced Hypersensitivity
92. Nikakhlagh S, et al Herbal treatment of allergic rhinitis: the use of Nigella sativa . Am J Otolaryngol. (2011)
93. Kalus U, et al Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases . Phytother Res. (2003)
94. Boskabady MH, et al The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients . Fundam Clin Pharmacol. (2007)
95. Chehl N, et al Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells . HPB (Oxford). (2009)
96. Gheita TA, Kenawy SA Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study . Phytother Res. (2012)
97. Observations on the Biological Effects of Black Cumin Seed (Nigella sativa) and Green Tea (Camellia sinensis)
98. Salem ML, Hossain MS Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection . Int J Immunopharmacol. (2000)
99. Barakat EM, El Wakeel LM, Hagag RS Effects of Nigella sativa on outcome of hepatitis C in Egypt . World J Gastroenterol. (2013)
100. Effects of Oral Administration of Water Extract of Nigella sativa on the Hypothalamus Pituitary Adrenal Axis in Experimental Diabetes
101. Mansour SW, et al Sensibility of male rats fertility against olive oil, Nigella sativa oil and pomegranate extract . Asian Pac J Trop Biomed. (2013)
102. Boskabady MH, Keyhanmanesh R, Saadatloo MA Relaxant effects of different fractions from Nigella sativa L. on guinea pig tracheal chains and its possible mechanism(s) . Indian J Exp Biol. (2008)
103. The Contribution of Water and Lipid Soluble Substances in the Relaxant Effects of Nigella sativa Extract on Guinea Pig Tracheal Smooth Muscle (in vitro)
104. Boskabady MH, et al Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig . BMC Pharmacol. (2004)
105. el Tahir KE, Ashour MM, al-Harbi MM The respiratory effects of the volatile oil of the black seed (Nigella sativa) in guinea-pigs: elucidation of the mechanism(s) of action . Gen Pharmacol. (1993)
106. Boskabady MH, Farhadi J The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial . J Altern Complement Med. (2008)
107. Toppozada HH, Mazloum HA, el-Dakhakhny M The antibacterial properties of the Nigella sativa l. seeds. Active principle with some clinical applications . J Egypt Med Assoc. (1965)
108. Hanafy MS, Hatem ME Studies on the antimicrobial activity of Nigella sativa seed (black cumin) . J Ethnopharmacol. (1991)
109. Morsi NM Antimicrobial effect of crude extracts of Nigella sativa on multiple antibiotics-resistant bacteria . Acta Microbiol Pol. (2000)
110. O'Mahony R, et al Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori . World J Gastroenterol. (2005)
111. Salem EM, et al Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia . Saudi J Gastroenterol. (2010)
112. Gerrits MM, et al Helicobacter pylori and antimicrobial resistance: molecular mechanisms and clinical implications . Lancet Infect Dis. (2006)
113. Gault MH, Chafe L Relationship of frequency, age, sex, stone weight and composition in 15,624 stones: comparison of resutls for 1980 to 1983 and 1995 to 1998 . J Urol. (2000)
114. Coe FL, Evan A, Worcester E Kidney stone disease . J Clin Invest. (2005)
115. Rule AD, et al Kidney stones and the risk for chronic kidney disease . Clin J Am Soc Nephrol. (2009)
116. Hadjzadeh MA, et al The preventive effect of N-butanol fraction of Nigella sativa on ethylene glycol-induced kidney calculi in rats . Pharmacogn Mag. (2011)
117. Hadjzadeh MA, et al Ethanolic extract of nigella sativa L seeds on ethylene glycol-induced kidney calculi in rats . Urol J. (2007)
118. Jemal A, et al Cancer statistics, 2007 . CA Cancer J Clin. (2007)
119. Maisonneuve P, Lowenfels AB Chronic pancreatitis and pancreatic cancer . Dig Dis. (2002)
120. Rocca G, et al Increased incidence of cancer in chronic pancreatitis . J Clin Gastroenterol. (1987)
121. Liptay S, et al Mitogenic and antiapoptotic role of constitutive NF-kappaB/Rel activity in pancreatic cancer . Int J Cancer. (2003)
122. Fujioka S, et al Function of nuclear factor kappaB in pancreatic cancer metastasis . Clin Cancer Res. (2003)
123. Abdel-Hamid NM, et al Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma . Environ Health Prev Med. (2013)
124. Ng WK, Yazan LS, Ismail M Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein . Toxicol In Vitro. (2011)
125. Hasan TN, et al Methanolic extract of Nigella sativa seed inhibits SiHa human cervical cancer cell proliferation through apoptosis . Nat Prod Commun. (2013)
126. Cytotoxicity of thymoquinone (TQ) from Nigella sativa towards human cervical carcinoma cells (HeLa)
127. Al-Ali A, et al Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats . J Ayub Med Coll Abbottabad. (2008)
128. Sabzghabaee AM, et al Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial . Med Arh. (2012)
129. Gheita TA, Kenawy SA Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study . Phytother Res. (2012)
130. Bamosa AO, et al Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus . Indian J Physiol Pharmacol. (2010)
131. Nikakhlagh S, et al Herbal treatment of allergic rhinitis: the use of Nigella sativa . Am J Otolaryngol. (2011)
132. Kalus U, et al Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases . Phytother Res. (2003)
133. Najmi A, et al Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome . Int J Diabetes Dev Ctries. (2008)
134. Işik H, et al Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients . Med Princ Pract. (2010)
135. Akhondian J, et al The effect of thymoquinone on intractable pediatric seizures (pilot study) . Epilepsy Res. (2011)
136. Qidwai W, et al Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial . J Altern Complement Med. (2009)
137. Dehkordi FR, Kamkhah AF Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension . Fundam Clin Pharmacol. (2008)
138. Boskabady MH, et al The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients . Fundam Clin Pharmacol. (2007)
139. Boskabady MH, Farhadi J The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial . J Altern Complement Med. (2008)
140. Datau EA, et al Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male . Acta Med Indones. (2010)
141. Barakat EM, El Wakeel LM, Hagag RS Effects of Nigella sativa on outcome of hepatitis C in Egypt . World J Gastroenterol. (2013)
142. Bin Sayeed MS, et al The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers . J Ethnopharmacol. (2013)
145. Adams RP. Identification of essential oil components by gas chromatography/mass spectrometry. 4. Carol Stream, and IL: Allured; 2007.
146. Akhondian J, Parsa A, Rakhshande H. The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures. Med Sci Monit. 2007;13:555–559. [PubMed]
147. Badary OA, Al-Shabanah OA, Nagi MN, Al-Rikabi AC, Almazar MMA. Inhibition of benzo (a) pyrene-induced forestomach carcinogenesis in mice by thymoquinone. Eur J Cancer Prev. 1999;8:435–440. doi: 10.1097/00008469-199910000-00009. [PubMed] [Cross Ref]
148. Badary OA, Gamal El-Din AM. Inhibitory effects of thymoquinone against 20-methyl cholanthrene-induced fibrosarcoma tumorigenesis. Cancer Detec Prev. 2001;25:362–368. [PubMed]
149. Badary OA, Taha RA, Gamal El-Din AM, Abdel-Wahab MH. Thymoquinone is a potent superoxide anion scavenger. Drug Chem Toxicol. 2003;26:87–98. doi: 10.1081/DCT-120020404. [PubMed] [Cross Ref]
150. Badary OA, Abd-Ellah MF, El-Mahdy MA, Salama SA, Hamada FM. Anticlastogenic activity of thymoquinone against benzo (a) pyrene in mice. Food Chem Toxicol. 2007;45:88–92. doi: 10.1016/j.fct.2006.08.004. [PubMed] [Cross Ref]
151. Benkaci-Ali F, Baaliouamer A, Meklati BY, Chemat F. Chemical composition of seed essential oils from Algerian Nigella sativa extracted by microwave and hydrodistillation. Flavour Fragr J. 2007;22:148–153. doi: 10.1002/ffj.1773. [Cross Ref]
152. Burits M, Bucar F. Antioxidant activity of Nigella sativa essential oil. Phytother Res. 2000;14:323–328. doi: 10.1002/1099-1573(200008)14:5<323::AID-PTR621>3.0.CO;2-Q. [PubMed] [Cross Ref]
153. Chakrabarty A, Emerson MR, LeVine SM. Heme oxygenase 1 in SJL mice with experimental allergic encephalomyelitis. Mult Scler. 2003;9:372–381. doi: 10.1191/1352458503ms928oa. [PubMed] [Cross Ref]
154. El-Dakhakhny M. Studies on the chemical constitution of Egyptian Nigella sativa L. seeds II the essential oil. Planta Med. 1963;11:465–470. doi: 10.1055/s-0028-1100266. [Cross Ref]
155. El-Ghorab AH. Supercritical fluid extraction of the Egyptian rosemary (Rosmarinus officinalis) leaves and Nigella sativa L. seeds volatile oils and their antioxidant activities. J Essent Oil Bear Plants. 2003;6:67–77.
156. Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, Roessner A. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol. 2004;25:857–866. [PubMed]
157. Gora J, Lis A, Kula J, Staniszewska M, Woloszyn A (2002) Chemical composition variability of essential oils in the ontogenesis of some plants. Flav Fragr J 445–451
158. Hajhashemi V, Ghannadi A, Jafarabadi H. Black cumin seed essential oil, as a potent analgesic and anti-inflammatory drug. Phytother Res. 2004;18:195–199. doi: 10.1002/ptr.1390. [PubMed] [Cross Ref]
159. Haq A, Lobo PI, Al-Tulfail M, Rama NR, Al-Sedairy ST. Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. Int J Immunopharmacol. 1999;21:283–295. doi: 10.1016/S0192-0561(99)00010-7. [PubMed] [Cross Ref]
160. Joulain D, Konig WA. The Atlas of spectral data of sesquiterpene hydrocarbons. Hamburg: E.B.-Verlag; 1998.
161. Kanter M. Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy. Neurochem Res. 2008;33:87–96. doi: 10.1007/s11064-007-9419-5. [PubMed] [Cross Ref]
162. Machmudah S, Shiramizu Y, Goto M, Sasaki M, Hirose T. Extraction of Nigella sativa L. using supercritical CO2: a study of antioxidant activity of the extract. Sep Sci Technol. 2005;40:1267–1275. doi: 10.1081/SS-200053005. [Cross Ref]
163. Mansour MA, Nagi MN, El-Khatib AS, Al-Bekairi AM. Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem Funct. 2002;20:143–151. doi: 10.1002/cbf.968. [PubMed] [Cross Ref]
164. Morikawa T, Xu F, Kashima Y, Matsuda H, Ninomiya K, Yoshikawa M. Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa. Org Lett. 2004;6:869–872. doi: 10.1021/ol036239c. [PubMed] [Cross Ref]
165. Mutabagani A, El-Mehdy SAM. A study of the antiinflammatory activity of Nigella sativa and thymoquinone in rats. Saudi Pharm J. 1997;5:110–113.
166. Omidbaigi R (1997) Approaches to production and processing of medicinal plants, vol. 2. Tarrahane Nashr Public, Tehran, p 14, 70–78, 166–184
167. Ravindran J, Nair HB, Sung B, Prasad S, Tekmal RR, Aggarwal BB. Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential. Biochem Pharmacol. 2010;79:1640–1647. doi: 10.1016/j.bcp.2010.01.023. [PMC free article] [PubMed] [Cross Ref] Retracted
168. Reineccius G (1994) Source Book of Flavors. Chapman & Hall. London, p73
169. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 2005;5:1749–1770. doi: 10.1016/j.intimp.2005.06.008. [PubMed] [Cross Ref]
170. Topozada HH, Masloum H, El-Dakhakhany M. The anti-bacterial properties of Nigella sativa seeds: active principle with some clinical application. J Egypt Med Assoc. 1965;48(suppl):187–202. [PubMed]
171. Udaya Sankar K. Studies on physico-chemical characteristic of essential oil of pepper (Pipernigrum L.) obtained by supercritical carbon dioxide. J Sci Food Agric. 1989;48:105–112.
172. Worthen DR, Ghosheh OA, Crooks PA. The in vitro anti-tumor activity of some crude and purified components of black seed, Nigella sativa. Anticancer Res. 1998;18:1527–1532. [PubMed]
173. ""The Plant List: A Working List of All Plant Species"".
174. ""BSBI List 2007"". Botanical Society of Britain and Ireland. Archived from the original (xls) on 2015-02-25. Retrieved 2014-10-17.
175. ""USDA GRIN Taxonomy"".
176. Heiss, Andreas (December 2005). ""The oldest evidence of Nigella damascena L. (Ranunculaceae) and its possible introduction to central Europe"". Vegetation History and Archaeobotany. 14 (4): 562–570. doi:10.1007/s00334-005-0060-4. JSTOR 23419312. (registration required (help)).
177. Hyam, R. & Pankhurst, R.J. (1995). Plants and their names : a concise dictionary. Oxford: Oxford University Press. ISBN 978-0-19-866189-4. p. 341.
178. Bharat B Aggarwal. Molecular Targets and Therapeutic Uses of Spices. Google Books. p. 259. ISBN 978-981-4468-95-4. Retrieved 4 January 2015.
179. Bunium persicum - (Boiss.) B.Fedtsch. Common Name Black Caraway
180. Bramen L (16 February 2011). ""Nigella Seeds: What the Heck Do I Do with Those?"". smithsonian.com. The Smithsonian Online. Retrieved 4 January 2015.
181. Zohary, Daniel; Hopf, Maria (2000). Domestication of plants in the Old World (3 ed.). Oxford University Press. p. 206. ISBN 0-19-850356-3.
182. Saliha B, Sipahib T, Oybak Dönmez, E (2009). ""Ancient nigella seeds from Boyalı Höyük in north-central Turkey"". Journal of Ethnopharmacology. 124 (3): 416–20. doi:10.1016/j.jep.2009.05.039.
183. Avicenna (1999). Canon of Medicine. Chicago: Kazi Publications.
184. Mohammad Hossein Boskabady; Batool Shirmohammadi (2002). ""Effect of Nigella Sativa on Isolated Guinea Pig Trachea"" (PDF). Arch. Iran. Med. 5 (2): 103–107.
185. Ali BH, Blunden G (2003). ""Pharmacological and toxicological properties of Nigella sativa"". Phytother Res. 17 (4): 299–305. doi:10.1002/ptr.1309. PMID 12722128.
186. Sahebkar A, Soranna D, Liu X, et al. (2016). ""A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure"". J Hypertens. 34 (11): 2127–35. doi:10.1097/HJH.0000000000001049. PMID 27512971.
187. Sahebkar A, Beccuti G, Simental-Mendía LE, et al. (2016). ""Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials"". Pharmacol Res. 106: 37–50. doi:10.1016/j.phrs.2016.02.008. PMID 26875640.
192. Adem Ahlatci, Abdurahman Kuzhan, Seyithan Taysi, Omer Can Demirtas, Hilal Eryigit Alkis, Mehmet Tarakcioglu, Ali Demirci, Derya Caglayan, Edibe Saricicek, Kadir Cinar. Radiation-modifying abilities of Nigella sativa and Thymoquinone on radiation-induced nitrosative stress in the brain tissue. Phytomedicine. 2013 Nov 21. pii: S0944-7113(13)00432-7. doi: 10.1016/j.phymed.2013.10.023. [Epub ahead of print]
193. Mohammad Akram Randhawa, Mastour Safar Alghamdi, Subir Kumar Maulik. The effect of thymoquinone, an active component of Nigella sativa, on isoproterenol induced myocardial injury. Pak J Pharm Sci. 2013 Nov;26(6):1215-9.
194. Milad Anvari, Atefeh Seddigh, Mohammad Naser Shafei, Hassan Rakhshandeh, Amir Hossein Talebi, Mohammad Reza Tahani, S Mohsen Saeedjalali, Mahmoud Hosseini. Nigella sativa extract affects conditioned place preference induced by morphine in rats. 2012 Oct;32(2):82-8. doi: 10.4103/0257-7941.118537.
195. Ola M Omran. Effects of Thymoquinone on STZ-induced Diabetic Nephropathy: An Immunohistochemical Study. Ultrastruct Pathol. 2013 Oct 17.
196. Ahmet Sahbaz, Firat Ersan, Serdar Aydin. Effect of Nigella sativa oil on postoperative peritoneal adhesion formation. J Obstet Gynaecol Res. 2013 Oct 7. doi: 10.1111/jog.12172.
197. Norsharina "
198. A review on therapeutic potential of Nigella sativa: A miracle herb https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642442/