Black Seed - Organic
- Black seed oil has a long history both medicinally and spiritually dating back 3000 years.
- This powerful seed and the oil it produces has been used and spoken about from Hippocrates to Cleopatra and has also been referenced in some of the oldest herbal books in history, as well as, the bible.
- Black seeds were also found in Tutankhamen’s tomb because it was believed to be important in the afterlife. When the tomb was exhumed there were seeds found in the tomb preserved in honey and it was said to still be edible.
- This powerful seed not only has the history but the modern science to back it up... More info
Earn a Discount!
Click the icons below to let people know about ZNF and receive a $1.00 discount coupon each time you share. 1$
Black seed is a true superfood
-- Used since Ancient times!
Black seed is a member of the Apiaceae family from the plant Nigella sativa. Its seeds are dark, thin and crescent shaped with approximately 100 chemical constituents present (some have not been identified). One of the constituents that has been studied by modern science as a major player in this food is thymoquinone.
Some of the other identified constituents are beta sitosterol, myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, arachidonic acid, protein, vitamin B1, vitamin B2, vitamin B3, folic acid, calcium, iron, copper, zinc, and phosphorous. Since 1959, black seed has been the subject of many different studies at universities and laboratories.
The compounds in black seed are a unique mixture that may have multiple supportive effects.
Antioxidants which may support the body’s ability to reduce oxidation, support antioxidant systems on a cellular level and possibly prevent damage caused by free radicals. Compounds that may support the body’s ability to have a healthy inflammation response. It may do this in 3 possible ways:
First, by possibly aiding in the suppression of NF-KappaB which is a master regulator of inflammation by preventing inflammation pathways from becoming over stimulated.
Second, it may possibly support the inhibition of a variety of enzymatic systems that produce leukotrienes and prostaglandins like 5-LOX and COX1.
Third, it may possibly support the reduction of a precursor of molecular inflammation called 5-HETE.
Black seed may have a possible direct effect on the body’s ability to have a healthy immune response by inciting an acute inflammatory response to infection.
Hair, skin and nails
It has been said that if you nourish what is on the inside it will show on the outside as well. It is believed that Cleopatra’s beauty came from the use of this powerful seed. Rich in nourishing compounds, vitamins and minerals necessary for the possible repair and recovery of one’s hair, skin and nails. Science has said that many of today’s skin issues have a direct connection to autoimmune issues.
26 different fatty acids
Much of the science with black seeds and skin health goes back to its ability to support the body in having a healthy inflammation and immune system response. This may be one of the links that puts it all together. Another possible connection is the very impressive essential fatty acid profile having 26 different fatty acids present like palmitic acid, linoleic acid, oleic acid, epa, dha and eicosatrienoic acid.
Due to the variety of ways this food may support human health and the impressive body of science and history backing it up, we would not be surprised if you see much more to come from this powerful superfood. We strongly encourage you to make this an everyday staple in your life.
Some possible traditional uses of Raw Organic Black Seeds may include:
May support a healthy immune system response
May support a healthy inflammation response
May support a healthy antioxidant response
May support the health of hair, skin, and nails
May support a healthy histamine and allergy response
May support healthy digestion
May support cardiovascular health
May support a variety of different regulatory pathways in the body
Possible antifungal and anti-yeast properties
Complex fatty acid profile
Complete body of science and history supporting its ability to nourish the body
Constituents of Black Seeds include:
Tricyclene, Camphene, β-Pinene, 2,4, nigellone, Dithymoquinone, Sabinene, β-Myrcene, 1,8-Cineole, α-Terpinene, Limonene, γ-Terpinene, cis-Sabinene hydrate, allo-Ocimenol, Linalool, Terpinolene, trans-Sabinene hydrate, Terpinen-1-ol, 1,5,8-p-Menthatriene, Nonane, Borneol, RI, MS, Pinocarvone, trans-Dihydrocarvone, Dihydrocarvone, Ocimenone (E), Thymoquinone, Thymol, Carvacrol, 2-Undecanone, n-Octyl isobutyrate, α-Longipinene, Citronellyl acetate, Thymohydroquinone methyl ether, Cyclosativene, tanethole, α-Longicyclene, 4-terpineol, beta sitosterol, (10)-Thujadiene, myristic acid, palmitoleic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, Oxygenated monoterpenes, Sesquiterpene hydrocarbons, Oxygenated sesquiterpenes, Diterpenes, Alkane, Alkenes, Fatty acids, Fatty acid esters, arachidonic acid, protein, vitamin B1, vitamin B2, vitamin B3, folic acid, calcium, iron, copper, zinc, and phosphorous, Epa, Dha, α-Copaene, α-Longifolene, (Z)-Caryophyllene, β-Caryophyllene, Thymohydroquinone dimethylether, RI, MS, Aromadendrene, Thymohydroquinone, Davanone, 8-Heptadecene, Dihydrofarnesyl acetate, Pimaradiene, Palmitic acid, Pimara-8(14),15-diene, Octadecanoic acid, Quinones, Monoterpene
Side Effects of Black Seeds:
There are no known side effects of black seeds, but it is best to take caution.
Black Seed has been reported to be toxic in the amount of 25 grams or more which is about 6 teaspoons.
Follow the suggested dosage requirements below.
Black seeds must be heated before taken. Eating black seeds that have not been heated will upset the stomach.
Do not take black seeds if you are pregnant.
Typical smell and flavor profile: Smoky and earthy flavor.
Common appearance and texture: Looks like a tiny black caraway seed.
As a garnish on top of traditional indian or any other dishes in order to kick the flavor profile up a notch.
Or just take 1 tsp for a nutritional boost.
How to Heat the Seeds:
Place the seeds in a skillet on low heat. Do not burn.
Stir the seeds often and taste until they lose their tartness -- the seeds must be bland.
The seeds should pop slightly in the skillet.
Remove from heat and let cool.
Miscellaneous Facts about our raw, organic Black Seeds
Certifications: USDA Certified Organic.
Ingredients: Raw Black Seeds.
Botanical Name: Nigella sativa L.
Other Names: Nigella seed, Great pignut, Kalaunji, upakunchika, nigella, Kalonji, Black cumin seeds, kala jeera, Susavi, Sthulajiraka, Blackseed, Upakunci, Black Cumin, Nigella seed, fennel flower, black caraway, nutmeg flower, black seeds, haba barakah, Roman coriander, Black caraway seeds.
Origin: Grown and harvested in India. Packaged with care in Florida, USA.
How to Maintain Optimum Freshness
ZNaturalFoods.com offers our raw, organic Black Seeds packaged in airtight stand-up, resealable foil pouches for optimum freshness.
Once opened, just push the air out of the pouch before resealing it in order to preserve maximum potency. Keep your raw, organic Black Seeds in a cool, dark, dry place.
About Z Natural Foods
Please go here to learn more about Z Natural Foods and discover the important steps we take to bring you fresh, quality nutrition.
Need to order a large quantity of our products? We’d be happy to help! Please contact our Bulk department to discuss the details.
California Residents: Click to view California Proposition 65 WARNING.
1. Qidwai W, et al Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial . J Altern Complement Med. (2009)
2. The medicinal potential of black seed (Nigella sativa) and its components
3. Ahmad A, et al A review on therapeutic potential of Nigella sativa: A miracle herb . Asian Pac J Trop Biomed. (2013)
4. Ali BH, Blunden G Pharmacological and toxicological properties of Nigella sativa . Phytother Res. (2003)
5. Işik H, et al Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients . Med Princ Pract. (2010)
6. Salem ML Immunomodulatory and therapeutic properties of the Nigella sativa L. seed . Int Immunopharmacol. (2005)
7. Chakravarty N Inhibition of histamine release from mast cells by nigellone . Ann Allergy. (1993)
8. Chemical composition and microflora of black cumin (Nigella sativa L.) seeds growing in Saudi Arabia
9. Houghton PJ, et al Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation . Planta Med. (1995)
10. Nickavar B, et al Chemical composition of the fixed and volatile oils of Nigella sativa L. from Iran . Z Naturforsch C. (2003)
11. Novel lipid constituents identified in seeds of Nigella sativa (Linn)
12. Nutritional profile of indigenous cultivar of black cumin seeds and antioxidant potential of its fixed and essential oil
13. Chemical composition of Nigella sativa L. seeds
14. Keyhanmanesh R, et al The main relaxant constituents of nigella sativa methanolic fraction on Guinea pig tracheal chains . Iran J Allergy Asthma Immunol. (2013)
15. Nigellidine — A new indazole alkaloid from the seeds of Nigella sativa
16. Ali Z, et al Nigellidine-4-O-sulfite, the first sulfated indazole-type alkaloid from the seeds of Nigella sativa . J Nat Prod. (2008)
17. Morikawa T, et al Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa . Org Lett. (2004)
18. Morikawa T, et al Nigellamines A3, A4, A5, and C, new dolabellane-type diterpene alkaloids, with lipid metabolism-promoting activities from the Egyptian medicinal food black cumin . Chem Pharm Bull (Tokyo). (2004)
19. Mehta BK, Pandit V, Gupta M New principles from seeds of Nigella sativa . Nat Prod Res. (2009)
20. Quantification and diversity in the black seeds (Nigella sativa L.): Gene stock of Pakistan for their composition of mineral nutrients
21. el Tahir KE, Ashour MM, al-Harbi MM The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action . Gen Pharmacol. (1993)
22. Gali-Muhtasib H, Roessner A, Schneider-Stock R Thymoquinone: a promising anti-cancer drug from natural sources . Int J Biochem Cell Biol. (2006)
23. Burits M, Bucar F Antioxidant activity of Nigella sativa essential oil . Phytother Res. (2000)
24. Ghosheh OA, Houdi AA, Crooks PA High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.) . J Pharm Biomed Anal. (1999)
25. STUDIES ON THE CHEMICAL CONSTITUTION OF EGYPTIAN NIGELLA SATIVA L. SEEDS. II1) THE ESSENTIAL OIL
26. Antibacterial Activity of Thymoquinone and Thymohydroquinone of Nigella sativa L. and Their Interaction with Some Antibiotics
27. Worthen DR, Ghosheh OA, Crooks PA The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L . Anticancer Res. (1998)
28. He SM, et al Structural and functional properties of human multidrug resistance protein 1 (MRP1/ABCC1) . Curr Med Chem. (2011)
29. Al-Jenoobi FI, et al Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects . Drug Metab Lett. (2010)
30. Alkharfy KM, et al Lepidium Sativum but not Nigella sativa Affects Carbamazepine Disposition in an Animal Model . Drug Metab Lett. (2013)
31. Magnusson MO, et al Pharmacodynamics of carbamazepine-mediated induction of CYP3A4, CYP1A2, and Pgp as assessed by probe substrates midazolam, caffeine, and digoxin . Clin Pharmacol Ther. (2008)
32. Kerr BM, et al Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation . Biochem Pharmacol. (1994)
33. Al-Jenoobi FI, et al Effects of Nigella sativa and Lepidium sativum on Cyclosporine Pharmacokinetics . Biomed Res Int. (2013)
34. Noble S, Markham A Cyclosporin. A review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (Neoral) . Drugs. (1995)
35. Alkharfy KM, et al Effects of Lepidium sativum, Nigella sativa and Trigonella foenum-graceum on Phenytoin Pharmacokinetics in Beagle Dogs . Phytother Res. (2013)
36. Chhun S, et al The cytochrome P-450 2C9/2C19 but not the ABCB1 genetic polymorphism may be associated with the liver cytochrome 3A4 induction by phenytoin . J Clin Psychopharmacol. (2012)
37. Wang H, et al Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin . J Biol Chem. (2004)
38. Gilani AH, et al Bronchodilator, spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji): a traditional herbal product with multiple medicinal uses . J Pak Med Assoc. (2001)
39. Sanz P AMP-activated protein kinase: structure and regulation . Curr Protein Pept Sci. (2008)
40. Benhaddou-Andaloussi A, et al Multiple molecular targets underlie the antidiabetic effect of Nigella sativa seed extract in skeletal muscle, adipocyte and liver cells . Diabetes Obes Metab. (2010)
41. Benhaddou-Andaloussi A, et al The In Vivo Antidiabetic Activity of Nigella sativa Is Mediated through Activation of the AMPK Pathway and Increased Muscle Glut4 Content . Evid Based Complement Alternat Med. (2011)
42. The biochemical consequences of hypoxia
43. Owen MR, Doran E, Halestrap AP Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain . Biochem J. (2000)
44. Turner N, et al Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action . Diabetes. (2008)
45. Le PM, et al The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat . J Ethnopharmacol. (2004)
46. Antidiabetic Activity of Nigella sativa. Seed Extract in Cultured Pancreatic β-cells, Skeletal Muscle Cells, and Adipocytes
47. Allan AM, Harris RA gamma-Aminobutyric acid agonists and antagonists alter chloride flux across brain membranes . Mol Pharmacol. (1986)
48. Krishek BJ, Moss SJ, Smart TG A functional comparison of the antagonists bicuculline and picrotoxin at recombinant GABAA receptors . Neuropharmacology. (1996)
49. Raza M, et al Potentiation of Valproate-induced Anticonvulsant Response by Nigella sativa Seed Constituents: The Role of GABA Receptors . Int J Health Sci (Qassim). (2008)
50. Hosseinzadeh H, Parvardeh S Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice . Phytomedicine. (2004)
51. Gilhotra N, Dhingra D Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels . Pharmacol Rep. (2011)
52. El-Mahmoudy A, et al Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages . Int Immunopharmacol. (2002)
53. Harvey BH, et al Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus . Psychopharmacology (Berl). (2004)
54. Robello M, et al Nitric oxide and GABAA receptor function in the rat cerebral cortex and cerebellar granule cells . Neuroscience. (1996)
55. Duan Y, et al Methylene blue blocks cGMP production and disrupts directed migration of microglia to nerve lesions in the leech CNS . J Neurobiol. (2003)
56. Al-Ghamdi MS The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa . J Ethnopharmacol. (2001)
57. Bin Sayeed MS, et al The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers . J Ethnopharmacol. (2013)
58. Akhtar M, et al Neuroprotective effects of chloroform and petroleum ether extracts of Nigella sativa seeds in stroke model of rat . J Pharm Bioallied Sci. (2013)
59. Hosseinzadeh H, et al Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats . Med Sci Monit. (2005)
60. Akhondian J, et al The effect of thymoquinone on intractable pediatric seizures (pilot study) . Epilepsy Res. (2011)
61. Dantzer R, et al Inflammation-associated depression: from serotonin to kynurenine . Psychoneuroendocrinology. (2011)
62. Maes M, et al The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression . Metab Brain Dis. (2009)
63. Hashioka S Antidepressants and neuroinflammation: Can antidepressants calm glial rage down . Mini Rev Med Chem. (2011)
64. Howren MB, Lamkin DM, Suls J Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis . Psychosom Med. (2009)
65. Dowlati Y, et al A meta-analysis of cytokines in major depression . Biol Psychiatry. (2010)
66. Dunn AJ, Swiergiel AH, de Beaurepaire R Cytokines as mediators of depression: what can we learn from animal studies . Neurosci Biobehav Rev. (2005)
67. Hosseini M, et al The effects of Nigella sativa hydro-alcoholic extract and thymoquinone on lipopolysaccharide - induced depression like behavior in rats . J Pharm Bioallied Sci. (2012)
68. Bin Sayeed MS1, et al Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males . J Ethnopharmacol. (2014)
69. Nigella sativa Oil Enhances the Spatial Working Memory Performance of Rats on a Radial Arm Maze
70. Seif AA Nigella sativa attenuates myocardial ischemic reperfusion injury in rats . J Physiol Biochem. (2013)
71. Dehkordi FR, Kamkhah AF Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension . Fundam Clin Pharmacol. (2008)
72. Datau EA, et al Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male . Acta Med Indones. (2010)
73. Sabzghabaee AM, et al Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial . Med Arh. (2012)
74. Bamosa AO, et al Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus . Indian J Physiol Pharmacol. (2010)
75. Najmi A, et al Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome . Int J Diabetes Dev Ctries. (2008)
76. Hamed A, Alobaidi A Effect of Nigella Sativa and Allium Sativum Coadminstered with Simvastatin in Dyslipidemia Patients: A Prospective, Randomized, Double-blind Trial . Antiinflamm Antiallergy Agents Med Chem. (2013)
77. Krieger M The other side of scavenger receptors: pattern recognition for host defense . Curr Opin Lipidol. (1997)
78. Woollard KJ Immunological aspects of atherosclerosis . Clin Sci (Lond). (2013)
79. Mahmood MS, et al The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide production . Phytother Res. (2003)
80. Mat MC, Mohamed AS, Hamid SS Primary human monocyte differentiation regulated by Nigella sativa pressed oil . Lipids Health Dis. (2011)
81. El-Dakhakhny M, et al The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions . Planta Med. (2002)
82. Rchid H, et al Nigella sativa seed extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets . Fundam Clin Pharmacol. (2004)
83. Kanter M, et al Partial regeneration/proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats . Tohoku J Exp Med. (2003)
84. Comparative Study on the Medicinal Plants Most Recommended by Traditional Practitioners in Morocco and Canada
85. Al-Awadi FM, Khattar MA, Gumaa KA On the mechanism of the hypoglycaemic effect of a plant extract . Diabetologia. (1985)
86. al-Awadi F, Fatania H, Shamte U The effect of a plants mixture extract on liver gluconeogenesis in streptozotocin induced diabetic rats . Diabetes Res. (1991)
87. Hasani-Ranjbar S, Jouyandeh Z, Abdollahi M A systematic review of anti-obesity medicinal plants - an update . J Diabetes Metab Disord. (2013)
88. Tripathi YB, Chaturvedi AP, Pandey N Effect of Nigella sativa seeds extracts on iNOS through antioxidant potential only: crude/total extract as molecular therapy drug . Indian J Exp Biol. (2012)
89. Haq A, et al Nigella sativa: effect on human lymphocytes and polymorphonuclear leukocyte phagocytic activity . Immunopharmacology. (1995)
90. Majdalawieh AF, Hmaidan R, Carr RI Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity . J Ethnopharmacol. (2010)
91. Anti-asthmatic and Anti-allergic Effects of Thymoquinone on Experimentally- Induced Hypersensitivity
92. Nikakhlagh S, et al Herbal treatment of allergic rhinitis: the use of Nigella sativa . Am J Otolaryngol. (2011)
93. Kalus U, et al Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases . Phytother Res. (2003)
94. Boskabady MH, et al The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients . Fundam Clin Pharmacol. (2007)
95. Chehl N, et al Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells . HPB (Oxford). (2009)
96. Gheita TA, Kenawy SA Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study . Phytother Res. (2012)
97. Observations on the Biological Effects of Black Cumin Seed (Nigella sativa) and Green Tea (Camellia sinensis)
98. Salem ML, Hossain MS Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection . Int J Immunopharmacol. (2000)
99. Barakat EM, El Wakeel LM, Hagag RS Effects of Nigella sativa on outcome of hepatitis C in Egypt . World J Gastroenterol. (2013)
100. Effects of Oral Administration of Water Extract of Nigella sativa on the Hypothalamus Pituitary Adrenal Axis in Experimental Diabetes
101. Mansour SW, et al Sensibility of male rats fertility against olive oil, Nigella sativa oil and pomegranate extract . Asian Pac J Trop Biomed. (2013)
102. Boskabady MH, Keyhanmanesh R, Saadatloo MA Relaxant effects of different fractions from Nigella sativa L. on guinea pig tracheal chains and its possible mechanism(s) . Indian J Exp Biol. (2008)
103. The Contribution of Water and Lipid Soluble Substances in the Relaxant Effects of Nigella sativa Extract on Guinea Pig Tracheal Smooth Muscle (in vitro)
104. Boskabady MH, et al Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig . BMC Pharmacol. (2004)
105. el Tahir KE, Ashour MM, al-Harbi MM The respiratory effects of the volatile oil of the black seed (Nigella sativa) in guinea-pigs: elucidation of the mechanism(s) of action . Gen Pharmacol. (1993)
106. Boskabady MH, Farhadi J The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial . J Altern Complement Med. (2008)
107. Toppozada HH, Mazloum HA, el-Dakhakhny M The antibacterial properties of the Nigella sativa l. seeds. Active principle with some clinical applications . J Egypt Med Assoc. (1965)
108. Hanafy MS, Hatem ME Studies on the antimicrobial activity of Nigella sativa seed (black cumin) . J Ethnopharmacol. (1991)
109. Morsi NM Antimicrobial effect of crude extracts of Nigella sativa on multiple antibiotics-resistant bacteria . Acta Microbiol Pol. (2000)
110. O'Mahony R, et al Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori . World J Gastroenterol. (2005)
111. Salem EM, et al Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia . Saudi J Gastroenterol. (2010)
112. Gerrits MM, et al Helicobacter pylori and antimicrobial resistance: molecular mechanisms and clinical implications . Lancet Infect Dis. (2006)
113. Gault MH, Chafe L Relationship of frequency, age, sex, stone weight and composition in 15,624 stones: comparison of resutls for 1980 to 1983 and 1995 to 1998 . J Urol. (2000)
114. Coe FL, Evan A, Worcester E Kidney stone disease . J Clin Invest. (2005)
115. Rule AD, et al Kidney stones and the risk for chronic kidney disease . Clin J Am Soc Nephrol. (2009)
116. Hadjzadeh MA, et al The preventive effect of N-butanol fraction of Nigella sativa on ethylene glycol-induced kidney calculi in rats . Pharmacogn Mag. (2011)
117. Hadjzadeh MA, et al Ethanolic extract of nigella sativa L seeds on ethylene glycol-induced kidney calculi in rats . Urol J. (2007)
118. Jemal A, et al Cancer statistics, 2007 . CA Cancer J Clin. (2007)
119. Maisonneuve P, Lowenfels AB Chronic pancreatitis and pancreatic cancer . Dig Dis. (2002)
120. Rocca G, et al Increased incidence of cancer in chronic pancreatitis . J Clin Gastroenterol. (1987)
121. Liptay S, et al Mitogenic and antiapoptotic role of constitutive NF-kappaB/Rel activity in pancreatic cancer . Int J Cancer. (2003)
122. Fujioka S, et al Function of nuclear factor kappaB in pancreatic cancer metastasis . Clin Cancer Res. (2003)
123. Abdel-Hamid NM, et al Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma . Environ Health Prev Med. (2013)
124. Ng WK, Yazan LS, Ismail M Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein . Toxicol In Vitro. (2011)
125. Hasan TN, et al Methanolic extract of Nigella sativa seed inhibits SiHa human cervical cancer cell proliferation through apoptosis . Nat Prod Commun. (2013)
126. Cytotoxicity of thymoquinone (TQ) from Nigella sativa towards human cervical carcinoma cells (HeLa)
127. Al-Ali A, et al Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats . J Ayub Med Coll Abbottabad. (2008)
128. Sabzghabaee AM, et al Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial . Med Arh. (2012)
129. Gheita TA, Kenawy SA Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study . Phytother Res. (2012)
130. Bamosa AO, et al Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus . Indian J Physiol Pharmacol. (2010)
131. Nikakhlagh S, et al Herbal treatment of allergic rhinitis: the use of Nigella sativa . Am J Otolaryngol. (2011)
132. Kalus U, et al Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases . Phytother Res. (2003)
133. Najmi A, et al Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome . Int J Diabetes Dev Ctries. (2008)
134. Işik H, et al Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients . Med Princ Pract. (2010)
135. Akhondian J, et al The effect of thymoquinone on intractable pediatric seizures (pilot study) . Epilepsy Res. (2011)
136. Qidwai W, et al Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial . J Altern Complement Med. (2009)
137. Dehkordi FR, Kamkhah AF Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension . Fundam Clin Pharmacol. (2008)
138. Boskabady MH, et al The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients . Fundam Clin Pharmacol. (2007)
139. Boskabady MH, Farhadi J The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial . J Altern Complement Med. (2008)
140. Datau EA, et al Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male . Acta Med Indones. (2010)
141. Barakat EM, El Wakeel LM, Hagag RS Effects of Nigella sativa on outcome of hepatitis C in Egypt . World J Gastroenterol. (2013)
142. Bin Sayeed MS, et al The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers . J Ethnopharmacol. (2013)
145. Adams RP. Identification of essential oil components by gas chromatography/mass spectrometry. 4. Carol Stream, and IL: Allured; 2007.
146. Akhondian J, Parsa A, Rakhshande H. The effect of Nigella sativa L. (black cumin seed) on intractable pediatric seizures. Med Sci Monit. 2007;13:555–559. [PubMed]
147. Badary OA, Al-Shabanah OA, Nagi MN, Al-Rikabi AC, Almazar MMA. Inhibition of benzo (a) pyrene-induced forestomach carcinogenesis in mice by thymoquinone. Eur J Cancer Prev. 1999;8:435–440. doi: 10.1097/00008469-199910000-00009. [PubMed] [Cross Ref]
148. Badary OA, Gamal El-Din AM. Inhibitory effects of thymoquinone against 20-methyl cholanthrene-induced fibrosarcoma tumorigenesis. Cancer Detec Prev. 2001;25:362–368. [PubMed]
149. Badary OA, Taha RA, Gamal El-Din AM, Abdel-Wahab MH. Thymoquinone is a potent superoxide anion scavenger. Drug Chem Toxicol. 2003;26:87–98. doi: 10.1081/DCT-120020404. [PubMed] [Cross Ref]
150. Badary OA, Abd-Ellah MF, El-Mahdy MA, Salama SA, Hamada FM. Anticlastogenic activity of thymoquinone against benzo (a) pyrene in mice. Food Chem Toxicol. 2007;45:88–92. doi: 10.1016/j.fct.2006.08.004. [PubMed] [Cross Ref]
151. Benkaci-Ali F, Baaliouamer A, Meklati BY, Chemat F. Chemical composition of seed essential oils from Algerian Nigella sativa extracted by microwave and hydrodistillation. Flavour Fragr J. 2007;22:148–153. doi: 10.1002/ffj.1773. [Cross Ref]
152. Burits M, Bucar F. Antioxidant activity of Nigella sativa essential oil. Phytother Res. 2000;14:323–328. doi: 10.1002/1099-1573(200008)14:5<323::AID-PTR621>3.0.CO;2-Q. [PubMed] [Cross Ref]
153. Chakrabarty A, Emerson MR, LeVine SM. Heme oxygenase 1 in SJL mice with experimental allergic encephalomyelitis. Mult Scler. 2003;9:372–381. doi: 10.1191/1352458503ms928oa. [PubMed] [Cross Ref]
154. El-Dakhakhny M. Studies on the chemical constitution of Egyptian Nigella sativa L. seeds II the essential oil. Planta Med. 1963;11:465–470. doi: 10.1055/s-0028-1100266. [Cross Ref]
155. El-Ghorab AH. Supercritical fluid extraction of the Egyptian rosemary (Rosmarinus officinalis) leaves and Nigella sativa L. seeds volatile oils and their antioxidant activities. J Essent Oil Bear Plants. 2003;6:67–77.
156. Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, Roessner A. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol. 2004;25:857–866. [PubMed]
157. Gora J, Lis A, Kula J, Staniszewska M, Woloszyn A (2002) Chemical composition variability of essential oils in the ontogenesis of some plants. Flav Fragr J 445–451
158. Hajhashemi V, Ghannadi A, Jafarabadi H. Black cumin seed essential oil, as a potent analgesic and anti-inflammatory drug. Phytother Res. 2004;18:195–199. doi: 10.1002/ptr.1390. [PubMed] [Cross Ref]
159. Haq A, Lobo PI, Al-Tulfail M, Rama NR, Al-Sedairy ST. Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. Int J Immunopharmacol. 1999;21:283–295. doi: 10.1016/S0192-0561(99)00010-7. [PubMed] [Cross Ref]
160. Joulain D, Konig WA. The Atlas of spectral data of sesquiterpene hydrocarbons. Hamburg: E.B.-Verlag; 1998.
161. Kanter M. Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy. Neurochem Res. 2008;33:87–96. doi: 10.1007/s11064-007-9419-5. [PubMed] [Cross Ref]
162. Machmudah S, Shiramizu Y, Goto M, Sasaki M, Hirose T. Extraction of Nigella sativa L. using supercritical CO2: a study of antioxidant activity of the extract. Sep Sci Technol. 2005;40:1267–1275. doi: 10.1081/SS-200053005. [Cross Ref]
163. Mansour MA, Nagi MN, El-Khatib AS, Al-Bekairi AM. Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem Funct. 2002;20:143–151. doi: 10.1002/cbf.968. [PubMed] [Cross Ref]
164. Morikawa T, Xu F, Kashima Y, Matsuda H, Ninomiya K, Yoshikawa M. Novel dolabellane-type diterpene alkaloids with lipid metabolism promoting activities from the seeds of Nigella sativa. Org Lett. 2004;6:869–872. doi: 10.1021/ol036239c. [PubMed] [Cross Ref]
165. Mutabagani A, El-Mehdy SAM. A study of the antiinflammatory activity of Nigella sativa and thymoquinone in rats. Saudi Pharm J. 1997;5:110–113.
166. Omidbaigi R (1997) Approaches to production and processing of medicinal plants, vol. 2. Tarrahane Nashr Public, Tehran, p 14, 70–78, 166–184
167. Ravindran J, Nair HB, Sung B, Prasad S, Tekmal RR, Aggarwal BB. Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential. Biochem Pharmacol. 2010;79:1640–1647. doi: 10.1016/j.bcp.2010.01.023. [PMC free article] [PubMed] [Cross Ref] Retracted
168. Reineccius G (1994) Source Book of Flavors. Chapman & Hall. London, p73
169. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 2005;5:1749–1770. doi: 10.1016/j.intimp.2005.06.008. [PubMed] [Cross Ref]
170. Topozada HH, Masloum H, El-Dakhakhany M. The anti-bacterial properties of Nigella sativa seeds: active principle with some clinical application. J Egypt Med Assoc. 1965;48(suppl):187–202. [PubMed]
171. Udaya Sankar K. Studies on physico-chemical characteristic of essential oil of pepper (Pipernigrum L.) obtained by supercritical carbon dioxide. J Sci Food Agric. 1989;48:105–112.
172. Worthen DR, Ghosheh OA, Crooks PA. The in vitro anti-tumor activity of some crude and purified components of black seed, Nigella sativa. Anticancer Res. 1998;18:1527–1532. [PubMed]
173. "The Plant List: A Working List of All Plant Species".
174. "BSBI List 2007". Botanical Society of Britain and Ireland. Archived from the original (xls) on 2015-02-25. Retrieved 2014-10-17.
175. "USDA GRIN Taxonomy".
176. Heiss, Andreas (December 2005). "The oldest evidence of Nigella damascena L. (Ranunculaceae) and its possible introduction to central Europe". Vegetation History and Archaeobotany. 14 (4): 562–570. doi:10.1007/s00334-005-0060-4. JSTOR 23419312. (registration required (help)).
177. Hyam, R. & Pankhurst, R.J. (1995). Plants and their names : a concise dictionary. Oxford: Oxford University Press. ISBN 978-0-19-866189-4. p. 341.
178. Bharat B Aggarwal. Molecular Targets and Therapeutic Uses of Spices. Google Books. p. 259. ISBN 978-981-4468-95-4. Retrieved 4 January 2015.
179. Bunium persicum - (Boiss.) B.Fedtsch. Common Name Black Caraway
180. Bramen L (16 February 2011). "Nigella Seeds: What the Heck Do I Do with Those?". smithsonian.com. The Smithsonian Online. Retrieved 4 January 2015.
181. Zohary, Daniel; Hopf, Maria (2000). Domestication of plants in the Old World (3 ed.). Oxford University Press. p. 206. ISBN 0-19-850356-3.
182. Saliha B, Sipahib T, Oybak Dönmez, E (2009). "Ancient nigella seeds from Boyalı Höyük in north-central Turkey". Journal of Ethnopharmacology. 124 (3): 416–20. doi:10.1016/j.jep.2009.05.039.
183. Avicenna (1999). Canon of Medicine. Chicago: Kazi Publications.
184. Mohammad Hossein Boskabady; Batool Shirmohammadi (2002). "Effect of Nigella Sativa on Isolated Guinea Pig Trachea" (PDF). Arch. Iran. Med. 5 (2): 103–107.
185. Ali BH, Blunden G (2003). "Pharmacological and toxicological properties of Nigella sativa". Phytother Res. 17 (4): 299–305. doi:10.1002/ptr.1309. PMID 12722128.
186. Sahebkar A, Soranna D, Liu X, et al. (2016). "A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure". J Hypertens. 34 (11): 2127–35. doi:10.1097/HJH.0000000000001049. PMID 27512971.
187. Sahebkar A, Beccuti G, Simental-Mendía LE, et al. (2016). "Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials". Pharmacol Res. 106: 37–50. doi:10.1016/j.phrs.2016.02.008. PMID 26875640.
192. Adem Ahlatci, Abdurahman Kuzhan, Seyithan Taysi, Omer Can Demirtas, Hilal Eryigit Alkis, Mehmet Tarakcioglu, Ali Demirci, Derya Caglayan, Edibe Saricicek, Kadir Cinar. Radiation-modifying abilities of Nigella sativa and Thymoquinone on radiation-induced nitrosative stress in the brain tissue. Phytomedicine. 2013 Nov 21. pii: S0944-7113(13)00432-7. doi: 10.1016/j.phymed.2013.10.023. [Epub ahead of print]
193. Mohammad Akram Randhawa, Mastour Safar Alghamdi, Subir Kumar Maulik. The effect of thymoquinone, an active component of Nigella sativa, on isoproterenol induced myocardial injury. Pak J Pharm Sci. 2013 Nov;26(6):1215-9.
194. Milad Anvari, Atefeh Seddigh, Mohammad Naser Shafei, Hassan Rakhshandeh, Amir Hossein Talebi, Mohammad Reza Tahani, S Mohsen Saeedjalali, Mahmoud Hosseini. Nigella sativa extract affects conditioned place preference induced by morphine in rats. 2012 Oct;32(2):82-8. doi: 10.4103/0257-7941.118537.
195. Ola M Omran. Effects of Thymoquinone on STZ-induced Diabetic Nephropathy: An Immunohistochemical Study. Ultrastruct Pathol. 2013 Oct 17.
196. Ahmet Sahbaz, Firat Ersan, Serdar Aydin. Effect of Nigella sativa oil on postoperative peritoneal adhesion formation. J Obstet Gynaecol Res. 2013 Oct 7. doi: 10.1111/jog.12172.
197. Norsharina Ismail, Maznah Ismail, Musalmah Mazlan, Latiffah Abdul Latiff, Mustapha Umar Imam, Shahid Iqbal, Nur Hanisah Azmi, Siti Aisyah Abd Ghafar, Kim Wei Chan. Thymoquinone Preventsβ-Amyloid Neurotoxicity in Primary Cultured Cerebellar Granule Neurons. 2013 Nov;33(8):1159-69. doi: 10.1007/s10571-013-9982-z. Epub 2013 Oct 8.
198. Chern Chiuh Woo, Annie Hsu, Alan Prem Kumar, Gautam Sethi, Kwong Huat Benny Tan. Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS. 2013 Oct 2;8(10):e75356. doi: 10.1371/journal.pone.0075356. PMID: 24098377
199. Shashi Rajput, B N Prashanth Kumar, Kaushik Kumar Dey, Ipsita Pal, Aditya Parekh, Mahitosh Mandal. Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells. 2013 Nov 13;93(21):783-90. doi: 10.1016/j.lfs.2013.09.009. Epub 2013 Sep 15. PMID: 24044882
200. Lalitha Priyanka Dwarampudi, Dhanabal Palaniswamy, Muruganantham Nithyanantham, P S Raghu. Antipsoriatic activity and cytotoxicity of ethanolic extract of Nigella sativa seeds. 2012 Oct;8(32):268-72. doi: 10.4103/0973-1296.103650. PMID:24082629
201. A H Alhebshi, A Odawara, M Gotoh, I Suzuki. Thymoquinone protects cultured hippocampal and human induced pluripotent stem cells-derived neurons againstα-synuclein-induced synapse damage. Neurosci Lett. 2013 Sep 27. pii: S0304-3940(13)00873-2. doi: 10.1016/j.neulet.2013.09.049. PMID: 24080376
202. Ira O Racoma, Walter Hans Meisen, Qi-En Wang, Balveen Kaur, Altaf A Wani. Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells. 2013 Sep 9;8(9):e72882. doi: 10.1371/journal.pone.0072882. PMID: 24039814
203. Landa Zeenelabdin Ali Salim, Syam Mohan, Rozana Othman, Siddig Ibrahim Abdelwahab, Behnam Kamalidehghan, Bassem Y Sheikh, Mohamed Yousif Ibrahim. Thymoquinone induces mitochondria-mediated apoptosis in acute lymphoblastic leukaemia in vitro. . 2013 Sep 12;18(9):11219-40. doi: 10.3390/molecules180911219. PMID: 24036512
204. Subramanian Raghunandhakumar, Arumugam Paramasivam, Selvam Senthilraja, Chandrasekar Naveenkumar, Selvamani Asokkumar, John Binuclara, Sundaram Jagan, Pandi Anandakumar, Thiruvengadam Devaki. Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma. 2013 Oct 23;223(1):60-72. doi: 10.1016/j.toxlet.2013.08.018. Epub 2013 Sep 3. PMID:24012840
205. Samad Alimohammadi, Rahim Hobbenaghi, Javad Javanbakht, Danial Kheradmand, Reza Mortezaee, Maryam Tavakoli, Farshid Khadivar, Hamid Akbari. Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: an experimental study with histopathological evaluation. PMID: 23947821
206. Cagri Sakalar, Merve Yuruk, Tugba Kaya, Metin Aytekin, Salih Kuk, Halit Canatan. Pronounced transcriptional regulation of apoptotic and TNF-NF-kappa-B signaling genes during the course of thymoquinone mediated apoptosis in HeLa cells. Mol Cell Biochem. 2013 Nov;383(1-2):243-51. doi: 10.1007/s11010-013-1772-x. Epub 2013 Aug 14.PMID: 23943306
207. Khaled Radad, Khaled Hassanein, Mubarak Al-Shraim, Rudolf Moldzio, Wolf-Dieter Rausch. Thymoquinone ameliorates lead-induced brain damage in Sprague Dawley rats. PMID: 23910425
208. Ehab Abdelfadil, Ya-Hsin Cheng, Da-Tian Bau, Wei-Jen Ting, Li-Mien Chen, Hsi-Hsien Hsu, Yueh-Min Lin, Ray-Jade Chen, Fu-Jenn Tsai, Chang-Hai Tsai, Chih-Yang Huang. Thymoquinone induces apoptosis in oral cancer cells through p38β inhibition.
Great Stuff!I have a special process I use on all seed and nut products; first I pre-sprout them for 20hrs (to get rid of the enzyme blockers), then I blend them in a 3hp commercial blender until the temperature reaches 110 degrees (to get rid of the absorption inhibitors) and then I ferment them with a 34 strain probiotic for 24hrs (to get rid of the lectins which are the root cause of almost all ailments, and also because it keeps longer when fermented) before refrigerating it.
I've notice a marked improvement in my health since I started using them.